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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLK4 All Species: 10
Human Site: S515 Identified Species: 22
UniProt: O00444 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00444 NP_055079.3 970 108972 S515 P D L Q K D T S K N A W T D T
Chimpanzee Pan troglodytes XP_517431 973 109258 S515 P D L Q K D T S K N A R T D T
Rhesus Macaque Macaca mulatta XP_001105577 970 108780 S515 P D L Q K D T S K N A W T D T
Dog Lupus familis XP_533295 969 109039 D514 Q G H P D L Q D T S R N A W T
Cat Felis silvestris
Mouse Mus musculus Q64702 925 103728 Y471 P N R D F Q D Y P D L Q D T L
Rat Rattus norvegicus B2GUY1 924 103752 P471 N R D F Q D Y P D V Q D T L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516165 519 56295 F66 L K N R M K P F T E K E V R H
Chicken Gallus gallus
Frog Xenopus laevis Q6PAD2 944 105622 S491 T P D T S S V S N M G G D F Y
Zebra Danio Brachydanio rerio Q7ZVS3 940 103466 H487 H S S S G S F H S E R G P I G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O97143 769 85869 G316 I R S V E N S G P Q Q V L P Q
Honey Bee Apis mellifera XP_623133 730 82506 L277 K N M N K G L L G D G I V D S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 97.3 88.7 N.A. 78.8 78.9 N.A. 30.6 N.A. 60.3 52.1 N.A. 28.9 35 N.A. N.A.
Protein Similarity: 100 99.3 98.8 93.7 N.A. 86.9 86.5 N.A. 40.4 N.A. 74.1 67.1 N.A. 45.2 50.7 N.A. N.A.
P-Site Identity: 100 93.3 100 6.6 N.A. 6.6 13.3 N.A. 0 N.A. 6.6 0 N.A. 0 13.3 N.A. N.A.
P-Site Similarity: 100 93.3 100 13.3 N.A. 20 20 N.A. 6.6 N.A. 6.6 0 N.A. 20 40 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 28 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 28 19 10 10 37 10 10 10 19 0 10 19 37 0 % D
% Glu: 0 0 0 0 10 0 0 0 0 19 0 10 0 0 0 % E
% Phe: 0 0 0 10 10 0 10 10 0 0 0 0 0 10 0 % F
% Gly: 0 10 0 0 10 10 0 10 10 0 19 19 0 0 10 % G
% His: 10 0 10 0 0 0 0 10 0 0 0 0 0 0 10 % H
% Ile: 10 0 0 0 0 0 0 0 0 0 0 10 0 10 0 % I
% Lys: 10 10 0 0 37 10 0 0 28 0 10 0 0 0 0 % K
% Leu: 10 0 28 0 0 10 10 10 0 0 10 0 10 10 10 % L
% Met: 0 0 10 0 10 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 10 19 10 10 0 10 0 0 10 28 0 10 0 0 0 % N
% Pro: 37 10 0 10 0 0 10 10 19 0 0 0 10 10 0 % P
% Gln: 10 0 0 28 10 10 10 0 0 10 19 10 0 0 10 % Q
% Arg: 0 19 10 10 0 0 0 0 0 0 19 10 0 10 10 % R
% Ser: 0 10 19 10 10 19 10 37 10 10 0 0 0 0 10 % S
% Thr: 10 0 0 10 0 0 28 0 19 0 0 0 37 10 37 % T
% Val: 0 0 0 10 0 0 10 0 0 10 0 10 19 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 19 0 10 0 % W
% Tyr: 0 0 0 0 0 0 10 10 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _